In an interview with Sky Sports Boxing, Holmes didn't mince words about the hypothetical bout.
"I ain't knocking Mike Tyson, but no.. George Forman would win in two seconds, he hit too hard."
Holmes, who held the heavyweight title from 1978 to 1985, spoke from experience. He shared the ring with Tyson and felt his power first-hand. Yet, he still favors Foreman's punching prowess.
"Anybody come at George Foreman you got to box like I did, or Ali did, you can't stay there and take those punches. They take your head off. Bam, bam, it's like the kitchen sink he's hitting you with."
Foreman's career was marked by incredible achievements. He won his first world title in 1973 by knocking out Joe Frazier. After a 10-year break, he made a stunning comeback in 1987. In 1994, at 45, he became the oldest heavyweight champion ever by defeating Michael Moorer. Sadly, Foreman passed away recently at the age of 76.
Tyson, known as 'Iron Mike', burst onto the scene with 19 straight knockout wins to start his pro career. In 1986, he became the youngest heavyweight champion ever, stopping Trevor Berbick in the second round for the WBC title.
The potential Foreman-Tyson match was a hot topic in the 1990s. Fans and pundits alike wondered what would happen if these two knockout artists met in the ring. But the fight never materialized, partly due to Foreman's quest to regain a world title and Tyson's shocking loss to Buster Douglas.
Tyson recently returned to the ring at 58 years old. He faced Jake Paul last November at AT&T; Stadium in Texas, losing a unanimous decision.
While we'll never know for sure how a Foreman-Tyson fight would have played out, Holmes' opinion adds an interesting perspective to this enduring boxing debate.