Crawford stopped Spence in the ninth round of their undisputed welterweight title fight, taking the IBF, WBA, and WBC belts. Now, 'Bud' looks to make history by challenging Canelo for his 168 lb titles in September.
Spence shared his thoughts on the potential matchup in a recent interview.
"If Crawford wants to challenge himself to be great then let him try to be great you know, so I'm with it. I'll be going for him. I don't know if he's going to win or lose but I'll definitely be going for Crawford. I think if anybody can pull it off he can pull it off. He's chasing greatness so why not."
The Texas native drew parallels between Crawford's ambitions and Canelo's past exploits. He pointed out that the Mexican star has also taken risks by moving up in weight.
"Canelo went up to 175 and fought Kovalev and fought the other guy [Bivol] too, so if he can do it, and he started at 147, so if he doing then why can't 'Bud' do it."
Crawford's already made history as a three-weight world champion and two-weight undisputed king. A win over Canelo would cement his legacy as one of the all-time greats.
Canelo's got his own plans, though. He'll face William Scull in May with the IBF title on the line. A win there would make him undisputed at super-middleweight, setting up a huge clash with Crawford.
Not everyone shares Spence's optimism. Vergil Ortiz thinks Canelo will be too big for Crawford. Many boxing fans agree, seeing it as a tough task for the Omaha native.
Spence's backing of Crawford shows there's no bad blood after their fight. He believes in Crawford's ability to make history, even against the odds.