On November 12 at UFC 281, Reyes lost by knockout in the first round to Ryan Spann. For the 32-year-old American, this defeat was the fourth in a row.
“Is it time for Dominic Reyes to end his career after what Ryan Spann did to him? This guy came close to becoming a champion against Jon Jones, but now he was knocked out by Jiří Prochazka, the current belt holder, and Jan Blachowicz, who was the champion. Now he doesn't fight champions, he lost to a fighter in Ryan Spann who won two fights in a row," Cormier said on the DC & RC podcast.