Dubois put Joshua down in the first round. He floored him two more times before the referee stopped the contest in the fifth. The win made Dubois the new IBF World Heavyweight Champion.
A record-breaking crowd of 98,000 fans packed Wembley to watch the action. They saw Dubois come out aggressive and determined. He didn't let 'AJ' settle into the fight.
For Joshua, it was his fourth career loss and second by stoppage. After the fight, he said he "rolled the dice and came up short." Some people started to ask if Joshua should retire.
"Why? He had a bad day at the office ... I think he left everything in the dressing room."
That's what Derek Chisora told The Stomping Ground. The former heavyweight contender doesn't think Joshua needs to hang up his gloves just yet.
Chisora had high praise for the 27-year-old Dubois:
"Daniel was good. He came in as a true champion and left like a world champion ... Daniel now is number two in the world [behind Oleksandr Usyk]. If he stays on doing what he's doing he can go all the way."
Joshua carried British heavyweight boxing for years and took it to new heights. Now he's considering a rematch with Dubois. The landscape of the division has shifted dramatically with this result.
The BBC reported that the attendance of 98,000 broke records for a boxing event at Wembley Stadium. The fans got to witness a changing of the guard in British heavyweight boxing.