34-year-old Serrano had her last fight in September, defeating Sarah Mahfud on points. For the Puerto Rican, it was a return to the ring after losing to Kathy Taylor in April.
On the undercard Alicia Baumgardner (13-1, 7 KOs) and Elhem Mekhaled (15-1, 3 KOs) will fight for the WBA, WBO, IBF and WBC super featherweight titles. In New York, there will also be a fight between Sky Nicholson (5-0, 0 KOs) and Tanya Alvarez (7-0, 1 KOs) for the WBC featherweight silver belt and Ramla Ali (7-0, 2 KOs) against Avril Mathey (8-0-1, 3 KOs) for the IBF Intercontinental Bantamweight Championship.